Cyclin A2-CDK2 regulates embryonic gene activation in 1-cell mouse embryos
نویسندگان
چکیده
منابع مشابه
The structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent roles.
Cyclin E, an activator of phospho-CDK2 (pCDK2), is important for cell cycle progression in metazoans and is frequently overexpressed in cancer cells. It is essential for entry to the cell cycle from G0 quiescent phase, for the assembly of prereplication complexes and for endoreduplication in megakaryotes and giant trophoblast cells. We report the crystal structure of pCDK2 in complex with a tru...
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The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Src inhibitors increase cellular p27 stability, and Src overexpression accelerates p27 proteolysis. Src-phosphorylated p27 is shown to inhibit cyclin E-Cdk2 poorly in vitro, and Src t...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2005
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.07.012